Difference between revisions of "YOR278W"

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'''Description of YOR278W:''' Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathway<ref name='S000040301'>Amillet JM and Labbe-Bois R (1995) Isolation of the gene HEM4 encoding uroporphyrinogen III synthase in Saccharomyces cerevisiae. Yeast 11(5):419-24
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'''Description of YOR278W:''' Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria<ref name='S000040301'>Amillet JM and Labbe-Bois R (1995) Isolation of the gene HEM4 encoding uroporphyrinogen III synthase in Saccharomyces cerevisiae. Yeast 11(5):419-24 {{SGDpaper|S000040301}} PMID 7597845</ref><ref name='S000124836'>Tan FC, et al. (2008) Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase. Biochem J 410(2):291-9
  {{SGDpaper|S000040301}} PMID 7597845</ref>
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  {{SGDpaper|S000124836}} PMID 18042043</ref>
 
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Revision as of 14:05, 22 April 2009

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Systematic name YOR278W
Gene name HEM4
Aliases SLU2
Feature type ORF, Verified
Coordinates Chr XV:842816..843643
Primary SGDID S000005804


Description of YOR278W: Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria[1][2]




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References

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  1. Amillet JM and Labbe-Bois R (1995) Isolation of the gene HEM4 encoding uroporphyrinogen III synthase in Saccharomyces cerevisiae. Yeast 11(5):419-24 SGD PMID 7597845
  2. Tan FC, et al. (2008) Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase. Biochem J 410(2):291-9 SGD PMID 18042043

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