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Systematic name YOR048C
Gene name RAT1
Aliases HKE1, TAP1, XRN2
Feature type ORF, Verified
Coordinates Chr XV:421651..418631
Primary SGDID S000005574

Description of YOR048C: Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination[1][2][3]


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  1. Amberg DC, et al. (1992) Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA. Genes Dev 6(7):1173-89 SGD PMID 1628825
  2. Johnson AW (1997) Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively. Mol Cell Biol 17(10):6122-30 SGD PMID 9315672
  3. Kim M, et al. (2004) The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature 432(7016):517-22 SGD PMID 15565157

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