Difference between revisions of "YOR008C"

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==
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Transmembrane Domain GxxxG  ==
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The transmembrane domain of Slg1p/Wsc1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with vGaivGGvvGGvvG. The presence of multiple overlapping GxxxG motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Slg1p/Wsc1p multimerises.
  
  

Revision as of 08:43, 21 March 2013

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Systematic name YOR008C
Gene name SLG1
Aliases HCS77, WSC1
Feature type ORF, Verified
Coordinates Chr XV:342414..341278
Primary SGDID S000005534


Description of YOR008C: Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response[1][2][3][4]




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Community Commentary

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== Transmembrane Domain GxxxG ==

The transmembrane domain of Slg1p/Wsc1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with vGaivGGvvGGvvG. The presence of multiple overlapping GxxxG motifs [5] strongly indicates that Slg1p/Wsc1p multimerises.




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References

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  1. Gualtieri T, et al. (2004) The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae. Yeast 21(13):1107-20 SGD PMID 15484288
  2. Lodder AL, et al. (1999) Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Genetics 152(4):1487-99 SGD PMID 10430578
  3. Mao K, et al. (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67 SGD PMID 21576396
  4. Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9 SGD PMID 11545731
  5. Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242

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References

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