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Systematic name YOL149W
Gene name DCP1
Feature type ORF, Verified
Coordinates Chr XV:44938..45633
Primary SGDID S000005509

Description of YOL149W: Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p[1][2][3][4][5]


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  1. Beelman CA, et al. (1996) An essential component of the decapping enzyme required for normal rates of mRNA turnover. Nature 382(6592):642-6 SGD PMID 8757137
  2. Fischer N and Weis K (2002) The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1. EMBO J 21(11):2788-97 SGD PMID 12032091
  3. LaGrandeur TE and Parker R (1998) Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme. EMBO J 17(5):1487-96 SGD PMID 9482745
  4. She M, et al. (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat Struct Mol Biol 13(1):63-70 SGD PMID 16341225
  5. Vilela C, et al. (2000) The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex. EMBO J 19(16):4372-82 SGD PMID 10944120

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