YOL133W
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| Systematic name | YOL133W |
| Gene name | HRT1 |
| Aliases | HRT2, RBX1, ROC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:70325..70690 |
| Primary SGDID | S000005493 |
Description of YOL133W: RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF[1][2][3][4][5][6]
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References
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- ↑ Blondel M, et al. (2000) Isolation and characterization of HRT1 using a genetic screen for mutants unable to degrade Gic2p in saccharomyces cerevisiae. Genetics 155(3):1033-44 SGD PMID 10880467
- ↑ Kamura T, et al. (1999) Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science 284(5414):657-61 SGD PMID 10213691
- ↑ Ohta T, et al. (1999) ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell 3(4):535-41 SGD PMID 10230407
- ↑ Seol JH, et al. (1999) Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes Dev 13(12):1614-26 SGD PMID 10385629
- ↑ Skowyra D, et al. (1999) Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science 284(5414):662-5 SGD PMID 10213692
- ↑ Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 SGD PMID 10465783
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