Difference between revisions of "YOL100W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005460 YOL100W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PKH2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PKH2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr XV:129237..132482 | |nowrap| Chr XV:129237..132482 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005460 | ||
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| − | '''Description of | + | '''Description of YOL100W:''' Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p<ref name='S000071423'>Roelants FM, et al. (2002) Pkh1 and pkh2 differentially phosphorylate and activate ypk1 and ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28 {{SGDpaper|S000071423}} PMID 12221112</ref><ref name='S000069021'>Friant S, et al. (2001) Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J 20(23):6783-92 {{SGDpaper|S000069021}} PMID 11726514</ref><ref name='S000053842'>Casamayor A, et al. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97 {{SGDpaper|S000053842}} PMID 10074427</ref><ref name='S000048917'>Inagaki M, et al. (1999) PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol 19(12):8344-52 |
{{SGDpaper|S000048917}} PMID 10567559</ref> | {{SGDpaper|S000048917}} PMID 10567559</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 08:46, 27 February 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YOL100W |
| Gene name | PKH2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:129237..132482 |
| Primary SGDID | S000005460 |
Description of YOL100W: Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p[1][2][3][4]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [5] [6]
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References
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- ↑ Roelants FM, et al. (2002) Pkh1 and pkh2 differentially phosphorylate and activate ypk1 and ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28 SGD PMID 12221112
- ↑ Friant S, et al. (2001) Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J 20(23):6783-92 SGD PMID 11726514
- ↑ Casamayor A, et al. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97 SGD PMID 10074427
- ↑ Inagaki M, et al. (1999) PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol 19(12):8344-52 SGD PMID 10567559
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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