Difference between revisions of "YOL034W"
SGDwikiBot (talk | contribs) (Automated import of articles) |
SGDwikiBot (talk | contribs) (Automated import of articles) |
||
| Line 18: | Line 18: | ||
|} | |} | ||
<br> | <br> | ||
| − | '''Description of YOL034W:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair | + | '''Description of YOL034W:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91 {{SGDpaper|S000069988}} PMID 11927594</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 |
{{SGDpaper|S000080949}} PMID 15738391</ref> | {{SGDpaper|S000080949}} PMID 15738391</ref> | ||
<br> | <br> | ||
Revision as of 14:05, 25 February 2010
Share your knowledge...Edit this entry! <protect>
| Systematic name | YOL034W |
| Gene name | SMC5 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:259924..263205 |
| Primary SGDID | S000005394 |
Description of YOL034W: Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair[1][2][3]
</protect>
Community Commentary
About Community Commentary. Please share your knowledge!
Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination [4] and it is recruited to DNA double strand breaks to promote sister chromatid recombination [5]. The essential function of the Smc5-Smc6 complex is most probably related to chromosome segregation. The Smc5-Smc6 complex binds to the ribosomal DNA array (rDNA) [6] and smc5-smc6 thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature [7] [8]
<protect>
References
See Help:References on how to add references
- ↑ Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91 SGD PMID 11927594
- ↑ Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 SGD PMID 15010319
- ↑ Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 SGD PMID 15738391
- ↑ Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39
- ↑ de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4
- ↑ Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9
- ↑ Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9
- ↑ Cost GJ, Cozzarelli NR (2006) Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics 172(4):2185-200.
See Help:Categories on how to add the wiki page for this gene to a Category </protect> <protect>
References
See Help:References on how to add references
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
