Difference between revisions of "YOL026C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005386 YOL026C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MIM1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MIM1 '' | ||
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| − | '''Description of YOL026C:''' Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present | + | '''Description of YOL026C:''' Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex<ref name='S000136084'>Becker T, et al. (2008) Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J Biol Chem 283(1):120-7 {{SGDpaper|S000136084}} PMID 17974559</ref><ref name='S000146801'>Becker T, et al. (2011) The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. J Cell Biol 194(3):387-95 {{SGDpaper|S000146801}} PMID 21825073</ref><ref name='S000149341'>Dimmer KS, et al. (2012) A crucial role of Mim2 in the biogenesis of mitochondrial outer membrane proteins. J Cell Sci () {{SGDpaper|S000149341}} PMID 22467864</ref><ref name='S000129127'>Hulett JM, et al. (2008) The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex. J Mol Biol 376(3):694-704 {{SGDpaper|S000129127}} PMID 18187149</ref><ref name='S000077462'>Ishikawa D, et al. (2004) Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly. J Cell Biol 166(5):621-7 {{SGDpaper|S000077462}} PMID 15326197</ref><ref name='S000076598'>Mnaimneh S, et al. (2004) Exploration of essential gene functions via titratable promoter alleles. Cell 118(1):31-44 {{SGDpaper|S000076598}} PMID 15242642</ref><ref name='S000146327'>Papic D, et al. (2011) Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. J Cell Biol 194(3):397-405 {{SGDpaper|S000146327}} PMID 21825074</ref><ref name='S000081337'>Waizenegger T, et al. (2005) Mim1, a protein required for the assembly of the TOM complex of mitochondria. EMBO Rep 6(1):57-62 |
{{SGDpaper|S000081337}} PMID 15608614</ref> | {{SGDpaper|S000081337}} PMID 15608614</ref> | ||
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Latest revision as of 14:05, 3 May 2012
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| Systematic name | YOL026C |
| Gene name | MIM1 |
| Aliases | TOM13 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:274353..274012 |
| Primary SGDID | S000005386 |
Description of YOL026C: Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex[1][2][3][4][5][6][7][8]
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References
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- ↑ Becker T, et al. (2008) Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J Biol Chem 283(1):120-7 SGD PMID 17974559
- ↑ Becker T, et al. (2011) The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. J Cell Biol 194(3):387-95 SGD PMID 21825073
- ↑ Dimmer KS, et al. (2012) A crucial role of Mim2 in the biogenesis of mitochondrial outer membrane proteins. J Cell Sci () SGD PMID 22467864
- ↑ Hulett JM, et al. (2008) The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex. J Mol Biol 376(3):694-704 SGD PMID 18187149
- ↑ Ishikawa D, et al. (2004) Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly. J Cell Biol 166(5):621-7 SGD PMID 15326197
- ↑ Mnaimneh S, et al. (2004) Exploration of essential gene functions via titratable promoter alleles. Cell 118(1):31-44 SGD PMID 15242642
- ↑ Papic D, et al. (2011) Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. J Cell Biol 194(3):397-405 SGD PMID 21825074
- ↑ Waizenegger T, et al. (2005) Mim1, a protein required for the assembly of the TOM complex of mitochondria. EMBO Rep 6(1):57-62 SGD PMID 15608614
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