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Systematic name YOL018C
Gene name TLG2
Feature type ORF, Verified
Coordinates Chr XV:292074..290881
Primary SGDID S000005378

Description of YOL018C: Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)[1][2][3][4]


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  1. Bryant NJ and James DE (2001) Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation. EMBO J 20(13):3380-8 SGD PMID 11432826
  2. Coe JG, et al. (1999) A role for Tlg1p in the transport of proteins within the Golgi apparatus of Saccharomyces cerevisiae. Mol Biol Cell 10(7):2407-23 SGD PMID 10397773
  3. Dulubova I, et al. (2002) How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J 21(14):3620-31 SGD PMID 12110575
  4. Struthers MS, et al. (2009) Functional homology of mammalian syntaxin 16 and yeast Tlg2p reveals a conserved regulatory mechanism. J Cell Sci 122(Pt 13):2292-9 SGD PMID 19509055

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