Difference between revisions of "YOL013C"
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|nowrap| Chr XV:303036..301381 | |nowrap| Chr XV:303036..301381 | ||
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==Community Commentary== | ==Community Commentary== | ||
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Revision as of 08:18, 30 January 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YOL013C |
| Gene name | HRD1 |
| Aliases | DER3 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:303036..301381 |
Description of YOL013C: Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger[1][2][3][4][5][6]
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Contents
Community Commentary
About Community Commentary. Please share your knowledge!
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References
See Help:References on how to add references
- ↑ Gardner RG, et al. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151(1):69-82 SGD PMID 11018054
- ↑ Bays NW, et al. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3(1):24-9 SGD PMID 11146622
- ↑ Deak PM and Wolf DH (2001) Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276(14):10663-9 SGD PMID 11139575
- ↑ Friedlander R, et al. (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84 SGD PMID 10878801
- ↑ Hampton RY, et al. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44 SGD PMID 8970163
- ↑ Bordallo J, et al. (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9(1):209-22 SGD PMID 9437001
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