Difference between revisions of "YNR018W"

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'''Description of YNR018W:''' Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss<ref name='S000071347'>Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 {{SGDpaper|S000071347}} PMID 12140549</ref><ref name='S000131554'>Helbig AO, et al. (2009) A three-way proteomics strategy allows differential analysis of yeast mitochondrial membrane protein complexes under anaerobic and aerobic conditions. Proteomics 9(20):4787-98 {{SGDpaper|S000131554}} PMID 19750512</ref><ref name='S000129658'>Hess DC, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407 {{SGDpaper|S000129658}} PMID 19300474</ref><ref name='S000117178'>Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 {{SGDpaper|S000117178}} PMID 16823961</ref><ref name='S000075100'>Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
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'''Description of YNR018W:''' Protein with a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; member of the conserved hypoxia induced gene family; C. elegans ortholog is functional in yeast<ref name='S000131554'>Helbig AO, et al. (2009) A three-way proteomics strategy allows differential analysis of yeast mitochondrial membrane protein complexes under anaerobic and aerobic conditions. Proteomics 9(20):4787-98 {{SGDpaper|S000131554}} PMID 19750512</ref><ref name='S000148283'>Strogolova V, et al. (2012) Rcf1 and Rcf2, members of the hypoxia induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex. Mol Cell Biol ()
  {{SGDpaper|S000075100}} PMID 14576278</ref>
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  {{SGDpaper|S000148283}} PMID 22310663</ref>
 
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Revision as of 14:05, 10 February 2012

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Systematic name YNR018W
Gene name RCF2
Aliases AIM38
Feature type ORF, Verified
Coordinates Chr XIV:664270..664944
Primary SGDID S000005301


Description of YNR018W: Protein with a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; member of the conserved hypoxia induced gene family; C. elegans ortholog is functional in yeast[1][2]




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References

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  1. Helbig AO, et al. (2009) A three-way proteomics strategy allows differential analysis of yeast mitochondrial membrane protein complexes under anaerobic and aerobic conditions. Proteomics 9(20):4787-98 SGD PMID 19750512
  2. Strogolova V, et al. (2012) Rcf1 and Rcf2, members of the hypoxia induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex. Mol Cell Biol () SGD PMID 22310663

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