Difference between revisions of "YNL186W"

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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Revision as of 13:02, 21 February 2007

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Systematic name YNL186W
Gene name UBP10
Aliases DOT4
Feature type ORF, Verified
Coordinates Chr XIV:289500..291878


Description of YNL186W: Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus[1][2][3]




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Interactions

Two Hybrid

Two Hybrid interaction with SIR4
The N-terminal 250 aa of Ubp10p interacts with the C-terminus of Sir4p (residues 839-1358). [3] [4]




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References

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  1. Kahana A (2001) The deubiquitinating enzyme Dot4p is involved in regulating nutrient uptake. Biochem Biophys Res Commun 282(4):916-20 SGD PMID 11352638
  2. Singer MS, et al. (1998) Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics 150(2):613-32 SGD PMID 9755194
  3. 3.0 3.1 Kahana A and Gottschling DE (1999) DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6608-20 SGD PMID 10490600 Cite error: Invalid <ref> tag; name "S000042118" defined multiple times with different content
  4. submitted by Daniel E. Gottschling on 2003-03-17

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