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Systematic name YNL176C
Gene name TDA7
Feature type ORF, Uncharacterized
Coordinates Chr XIV:306980..305070
Primary SGDID S000005120

Description of YNL176C: Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele[1][2]


Community Commentary

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Transmembrane Domain GxxxG

The transmembrane domain of Tda7p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain contains GtivGsvvGsvgG. The presence of multiple, chained GxxxG motifs [3] strongly indicates that Tda7p multimerises.



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  1. Reid RJ, et al. (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86 SGD PMID 21173034
  2. de Lichtenberg U, et al. (2005) New weakly expressed cell cycle-regulated genes in yeast. Yeast 22(15):1191-201 SGD PMID 16278933
  3. Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242

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