Difference between revisions of "YNL098C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YNL098C YNL098C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005042 YNL098C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RAS2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RAS2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XIV:440572..439604
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|nowrap| Chr XIV:440570..439602
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000005042
 
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'''Description of {{PAGENAME}}:''' GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes<ref name='S000058484'>Bhattacharya S, et al. (1995) Ras membrane targeting is essential for glucose signaling but not for viability in yeast. Proc Natl Acad Sci U S A 92(7):2984-8 {{SGDpaper|S000058484}} PMID 7708760</ref><ref name='S000045204'>Kataoka T, et al. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37(2):437-45 {{SGDpaper|S000045204}} PMID 6327067</ref><ref name='S000041853'>Gimeno CJ, et al. (1992) Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68(6):1077-90
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'''Description of YNL098C:''' GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes<ref name='S000058484'>Bhattacharya S, et al. (1995) Ras membrane targeting is essential for glucose signaling but not for viability in yeast. Proc Natl Acad Sci U S A 92(7):2984-8 {{SGDpaper|S000058484}} PMID 7708760</ref><ref name='S000041853'>Gimeno CJ, et al. (1992) Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68(6):1077-90 {{SGDpaper|S000041853}} PMID 1547504</ref><ref name='S000045204'>Kataoka T, et al. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37(2):437-45
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  {{SGDpaper|S000041853}} PMID 1547504</ref>
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  {{SGDpaper|S000045204}} PMID 6327067</ref>
 
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==Community Commentary==
 
==Community Commentary==
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[[Category:Topic:Alleles, Strains, and Phenotypes:Other Mutation]]
 
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'''Strain Background''': W303-1B<br>
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'''Strain Background''': W303-1B (''see [[CommunityW303.html|detailed notes]] from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study'')
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'''Together with''': YFH1<br>
 
'''Together with''': YFH1<br>
 
'''Phenotype(s)''': Viable [[Category:Phenotype:Viable]]
 
'''Phenotype(s)''': Viable [[Category:Phenotype:Viable]]
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'''Strain Background''': W303-1B<br>
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'''Strain Background''': W303-1B (''see [[CommunityW303.html|detailed notes]] from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study'')
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'''Together with''': YFH1<br>
 
'''Together with''': YFH1<br>
 
'''Mutation type(s)''': partial deletion, deletion
 
'''Mutation type(s)''': partial deletion, deletion
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
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Latest revision as of 07:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YNL098C
Gene name RAS2
Aliases CTN5, CYR3, GLC5, TSL7
Feature type ORF, Verified
Coordinates Chr XIV:440570..439602
Primary SGDID S000005042


Description of YNL098C: GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes[1][2][3]




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Community Commentary

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Alleles, Strains, and Phenotypes

Other Mutation

Strain Background: W303-1B (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Together with: YFH1
Phenotype(s): Viable Mutation type(s): transposon insertion

A C-terminal truncation of RAS2 increased mRNA levels of CIT2 by a factor of two. [4] [5]

Interactions

Genetic

YNL098C is a suppressor of YFH1


Strain Background: W303-1B (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Together with: YFH1
Mutation type(s): partial deletion, deletion

A mutation in RAS2 supressed a growth defect of deltaYFH1 strain on toxic levels of iron in growth media. [4] [5]




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References

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  1. ↑ Bhattacharya S, et al. (1995) Ras membrane targeting is essential for glucose signaling but not for viability in yeast. Proc Natl Acad Sci U S A 92(7):2984-8 SGD PMID 7708760
  2. ↑ Gimeno CJ, et al. (1992) Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68(6):1077-90 SGD PMID 1547504
  3. ↑ Kataoka T, et al. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37(2):437-45 SGD PMID 6327067
  4. ↑ 4.0 4.1 Kucej M and Foury F (2003) Iron toxicity protection by truncated Ras2 GTPase in yeast strain lacking frataxin. Biochem Biophys Res Commun 310(3):986-91 SGD PMID 14550302
  5. ↑ 5.0 5.1 submitted by Martin Kucej on 2004-03-26

See Help:Categories on how to add the wiki page for this gene to a Category </protect> <protect>

References

See Help:References on how to add references

See Help:Categories on how to add the wiki page for this gene to a Category </protect>

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