YMR302C

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Systematic name YMR302C
Gene name YME2
Aliases PRP12, RNA12
Feature type ORF, Verified
Coordinates Chr XIII:872624..870072
Primary SGDID S000004917


Description of YMR302C: Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases[1][2][3][4]




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References

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  1. Thorsness PE and Fox TD (1993) Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus. Genetics 134(1):21-8 SGD PMID 8514129
  2. Hanekamp T and Thorsness PE (1999) YNT20, a bypass suppressor of yme1 yme2, encodes a putative 3'-5' exonuclease localized in mitochondria of Saccharomyces cerevisiae. Curr Genet 34(6):438-48 SGD PMID 9933355
  3. Hanekamp T and Thorsness PE (1996) Inactivation of YME2/RNA12, which encodes an integral inner mitochondrial membrane protein, causes increased escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae. Mol Cell Biol 16(6):2764-71 SGD PMID 8649384
  4. Park S, et al. (2006) Yme2p is a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae. Curr Genet 50(3):173-82 SGD PMID 16850347

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