YMR174C

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Systematic name YMR174C
Gene name PAI3
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:610364..610158
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Description of YMR174C: Cytoplasmic proteinase A inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact[1][2][3][4]



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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [5] [6]


References

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  1. Badasso MO, et al. (2000) Purification, co-crystallization and preliminary X--ray analysis of the natural aspartic proteinase inhibitor IA3 complexed with saccharopepsin from Saccharomyces cerevisiae. Acta Crystallogr D Biol Crystallogr 56(Pt 7):915-7 SGD PMID 10930843
  2. Beck I, et al. (1980) The intracellular proteinases and their inhibitors in yeast. A mutant with altered regulation of proteinase A inhibitor activity. J Biol Chem 255(10):4821-8 SGD PMID 6989820
  3. Phylip LH, et al. (2001) The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae. J Biol Chem 276(3):2023-30 SGD PMID 11042188
  4. Miralles VJ and Serrano R (1995) A genomic locus in Saccharomyces cerevisiae with four genes up-regulated by osmotic stress. Mol Microbiol 17(4):653-62 SGD PMID 8801420
  5. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  6. submitted by Viktor Boer on 2003-07-25

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