YMR167W
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| Systematic name | YMR167W |
| Gene name | MLH1 |
| Aliases | PMS2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:594885..597194 |
Description of YMR167W: Protein required for mismatch repair in mitosis and meiosis, postmeiotic segregation, and spore viability; forms a complex with Pms1p and Msh2p to repair mismatched DNA; human homolog is associated with hereditary non-polyposis colon cancer[1][2][3][4]
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References
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- ↑ Strand M, et al. (1993) Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365(6443):274-6 SGD PMID 8371783
- ↑ Bronner CE, et al. (1994) Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368(6468):258-61 SGD PMID 8145827
- ↑ Kolodner RD (1995) Mismatch repair: mechanisms and relationship to cancer susceptibility. Trends Biochem Sci 20(10):397-401 SGD PMID 8533151
- ↑ Prolla TA, et al. (1994) MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science 265(5175):1091-3 SGD PMID 8066446
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