Difference between revisions of "YMR167W"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:18, 30 January 2007

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Systematic name YMR167W
Gene name MLH1
Aliases PMS2
Feature type ORF, Verified
Coordinates Chr XIII:594885..597194


Description of YMR167W: Protein required for mismatch repair in mitosis and meiosis, postmeiotic segregation, and spore viability; forms a complex with Pms1p and Msh2p to repair mismatched DNA; human homolog is associated with hereditary non-polyposis colon cancer[1][2][3][4]




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Community Commentary

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References

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  1. Strand M, et al. (1993) Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365(6443):274-6 SGD PMID 8371783
  2. Bronner CE, et al. (1994) Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368(6468):258-61 SGD PMID 8145827
  3. Kolodner RD (1995) Mismatch repair: mechanisms and relationship to cancer susceptibility. Trends Biochem Sci 20(10):397-401 SGD PMID 8533151
  4. Prolla TA, et al. (1994) MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science 265(5175):1091-3 SGD PMID 8066446

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