Difference between revisions of "YMR070W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004674 YMR070W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MOT3 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MOT3 '' | ||
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''ROX7'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''ROX7, [MOT3+], [MOT3]'' |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | ||
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| − | '''Description of YMR070W:''' | + | '''Description of YMR070W:''' Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion<ref name='S000060147'>Abramova N, et al. (2001) Reciprocal regulation of anaerobic and aerobic cell wall mannoprotein gene expression in Saccharomyces cerevisiae. J Bacteriol 183(9):2881-7 {{SGDpaper|S000060147}} PMID 11292809</ref><ref name='S000039866'>Grishin AV, et al. (1998) Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae. Genetics 149(2):879-92 {{SGDpaper|S000039866}} PMID 9611199</ref><ref name='S000070244'>Hongay C, et al. (2002) Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae. EMBO J 21(15):4114-24 {{SGDpaper|S000070244}} PMID 12145211</ref><ref name='S000053629'>Kastaniotis AJ, et al. (2000) Roles of transcription factor Mot3 and chromatin in repression of the hypoxic gene ANB1 in yeast. Mol Cell Biol 20(19):7088-98 {{SGDpaper|S000053629}} PMID 10982825</ref><ref name='S000075225'>Mennella TA, et al. (2003) Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein. Eukaryot Cell 2(6):1288-303 {{SGDpaper|S000075225}} PMID 14665463</ref><ref name='S000144358'>Montanes FM, et al. (2011) Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors. Mol Microbiol 79(4):1008-23 {{SGDpaper|S000144358}} PMID 21299653</ref><ref name='S000074149'>Sertil O, et al. (2003) Synergistic repression of anaerobic genes by Mot3 and Rox1 in Saccharomyces cerevisiae. Nucleic Acids Res 31(20):5831-7 |
{{SGDpaper|S000074149}} PMID 14530431</ref> | {{SGDpaper|S000074149}} PMID 14530431</ref> | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YMR070W |
| Gene name | MOT3 |
| Aliases | ROX7, [MOT3+], [MOT3] |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:409154..410626 |
| Primary SGDID | S000004674 |
Description of YMR070W: Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion[1][2][3][4][5][6][7]
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References
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- ↑ Abramova N, et al. (2001) Reciprocal regulation of anaerobic and aerobic cell wall mannoprotein gene expression in Saccharomyces cerevisiae. J Bacteriol 183(9):2881-7 SGD PMID 11292809
- ↑ Grishin AV, et al. (1998) Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae. Genetics 149(2):879-92 SGD PMID 9611199
- ↑ Hongay C, et al. (2002) Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae. EMBO J 21(15):4114-24 SGD PMID 12145211
- ↑ Kastaniotis AJ, et al. (2000) Roles of transcription factor Mot3 and chromatin in repression of the hypoxic gene ANB1 in yeast. Mol Cell Biol 20(19):7088-98 SGD PMID 10982825
- ↑ Mennella TA, et al. (2003) Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein. Eukaryot Cell 2(6):1288-303 SGD PMID 14665463
- ↑ Montanes FM, et al. (2011) Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors. Mol Microbiol 79(4):1008-23 SGD PMID 21299653
- ↑ Sertil O, et al. (2003) Synergistic repression of anaerobic genes by Mot3 and Rox1 in Saccharomyces cerevisiae. Nucleic Acids Res 31(20):5831-7 SGD PMID 14530431
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