Difference between revisions of "YMR001C"
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| − | '''Description of YMR001C:''' Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate<ref name=' | + | '''Description of YMR001C:''' Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate<ref name='S000073294'>Hu F and Elledge SJ (2002) Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle 1(5):351-5 {{SGDpaper|S000073294}} PMID 12461298</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000074718'>Alexandru G, et al. (2001) Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell 105(4):459-72 |
| − | {{SGDpaper| | + | {{SGDpaper|S000074718}} PMID 11371343</ref> |
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Revision as of 13:05, 31 March 2009
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| Systematic name | YMR001C |
| Gene name | CDC5 |
| Aliases | MSD2, PKX2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:271136..269019 |
| Primary SGDID | S000004603 |
Description of YMR001C: Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [2] [4]
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References
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- ↑ Hu F and Elledge SJ (2002) Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle 1(5):351-5 SGD PMID 12461298
- ↑ 2.0 2.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Alexandru G, et al. (2001) Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell 105(4):459-72 SGD PMID 11371343
- ↑ submitted by Jeff Ubersax on 2004-01-29
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