Difference between revisions of "YML060W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YML060W YML060W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004525 YML060W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''OGG1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''OGG1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|nowrap| Chr XIII:151871..153001
 
|nowrap| Chr XIII:151871..153001
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000004525
 
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'''Description of {{PAGENAME}}:''' Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA<ref name='S000059916'>Singh KK, et al. (2001) Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants. Nucleic Acids Res 29(6):1381-8 {{SGDpaper|S000059916}} PMID 11239005</ref><ref name='S000047535'>Sandigursky M, et al. (1997) The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity. Nucleic Acids Res 25(22):4557-61 {{SGDpaper|S000047535}} PMID 9358166</ref><ref name='S000046294'>van der Kemp PA, et al. (1996) Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc Natl Acad Sci U S A 93(11):5197-202 {{SGDpaper|S000046294}} PMID 8643552</ref><ref name='S000046177'>Nash HM, et al. (1996) Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol 6(8):968-80
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'''Description of YML060W:''' Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance<ref name='S000086660'>Kozmin S, et al. (2005) UVA radiation is highly mutagenic in cells that are unable to repair 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 102(38):13538-43 {{SGDpaper|S000086660}} PMID 16157879</ref><ref name='S000046177'>Nash HM, et al. (1996) Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol 6(8):968-80 {{SGDpaper|S000046177}} PMID 8805338</ref><ref name='S000047535'>Sandigursky M, et al. (1997) The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity. Nucleic Acids Res 25(22):4557-61 {{SGDpaper|S000047535}} PMID 9358166</ref><ref name='S000059916'>Singh KK, et al. (2001) Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants. Nucleic Acids Res 29(6):1381-8 {{SGDpaper|S000059916}} PMID 11239005</ref><ref name='S000046294'>van der Kemp PA, et al. (1996) Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc Natl Acad Sci U S A 93(11):5197-202
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{{SGDpaper|S000046294}} PMID 8643552</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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S. cerevisiae ''OGG1'' gene was first cloned by functional complementation of E.coli fpg mutY double mutant. However, there is no obvious sequence homology betweeen these two proteins. The Ogg1 protein is conserved in eukaryotes, from yeat to mammals.
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<ref>van der Kemp, et al. (1996) Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine.
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Proc Natl Acad Sci U S A. 1996 May 28;93(11):5197-202.</ref>
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==References==
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==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YML060W
Gene name OGG1
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:151871..153001
Primary SGDID S000004525


Description of YML060W: Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance[1][2][3][4][5]




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Community Commentary

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http://wiki.yeastgenome.org/skins/common/images/button_italic.png Italic text

S. cerevisiae OGG1 gene was first cloned by functional complementation of E.coli fpg mutY double mutant. However, there is no obvious sequence homology betweeen these two proteins. The Ogg1 protein is conserved in eukaryotes, from yeat to mammals.



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References

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  1. ↑ Kozmin S, et al. (2005) UVA radiation is highly mutagenic in cells that are unable to repair 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 102(38):13538-43 SGD PMID 16157879
  2. ↑ Nash HM, et al. (1996) Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol 6(8):968-80 SGD PMID 8805338
  3. ↑ Sandigursky M, et al. (1997) The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity. Nucleic Acids Res 25(22):4557-61 SGD PMID 9358166
  4. ↑ Singh KK, et al. (2001) Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants. Nucleic Acids Res 29(6):1381-8 SGD PMID 11239005
  5. ↑ van der Kemp PA, et al. (1996) Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc Natl Acad Sci U S A 93(11):5197-202 SGD PMID 8643552

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References

See Help:References on how to add references

See Help:Categories on how to add the wiki page for this gene to a Category </protect>

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