Difference between revisions of "YML060W"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:18, 30 January 2007

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Systematic name YML060W
Gene name OGG1
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:151871..153001


Description of YML060W: Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA[1][2][3][4]




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Community Commentary

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References

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  1. Singh KK, et al. (2001) Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants. Nucleic Acids Res 29(6):1381-8 SGD PMID 11239005
  2. Sandigursky M, et al. (1997) The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity. Nucleic Acids Res 25(22):4557-61 SGD PMID 9358166
  3. van der Kemp PA, et al. (1996) Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc Natl Acad Sci U S A 93(11):5197-202 SGD PMID 8643552
  4. Nash HM, et al. (1996) Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol 6(8):968-80 SGD PMID 8805338

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