YML042W

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Systematic name YML042W
Gene name CAT2
Aliases YCAT
Feature type ORF, Verified
Coordinates Chr XIII:192788..194800
Primary SGDID S000004506


Description of YML042W: Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes[1][2][3]




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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [4] [5]


Protein Details

Other Protein Details

Other Topic: Regulated by the diauxic shift (glycerol)

Apart from the overall increase in mitochondrial protein mass this protein is induced after the diauxic shift. [6] [7]





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References

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  1. Elgersma Y, et al. (1995) Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene. EMBO J 14(14):3472-9 SGD PMID 7628448
  2. Swiegers JH, et al. (2001) Carnitine-dependent metabolic activities in Saccharomyces cerevisiae: three carnitine acetyltransferases are essential in a carnitine-dependent strain. Yeast 18(7):585-95 SGD PMID 11329169
  3. van Roermund CW, et al. (1999) Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p. EMBO J 18(21):5843-52 SGD PMID 10545096
  4. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  5. submitted by Viktor Boer on 2003-07-25
  6. Ohlmeier S, et al. (2004) The yeast mitochondrial proteome, a study of fermentative and respiratory growth. J Biol Chem 279(6):3956-79 SGD PMID 14597615
  7. submitted by Steffen Ohlmeier on 2004-04-08

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