YML014W

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Systematic name YML014W
Gene name TRM9
Aliases KTI1
Feature type ORF, Verified
Coordinates Chr XIII:243225..244064
Primary SGDID S000004476


Description of YML014W: tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin[1][2][3]




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References

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  1. Jablonowski D, et al. (2006) tRNAGlu wobble uridine methylation by Trm9 identifies Elongator's key role for zymocin-induced cell death in yeast. Mol Microbiol 59(2):677-88 SGD PMID 16390459
  2. Kalhor HR and Clarke S (2003) Novel methyltransferase for modified uridine residues at the wobble position of tRNA. Mol Cell Biol 23(24):9283-92 SGD PMID 14645538
  3. Studte P, et al. (2008) tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Mol Microbiol 69(5):1266-77 SGD PMID 18657261

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