Difference between revisions of "YLR425W"
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| − | '''Description of YLR425W:''' Guanine nucleotide exchange factor (GEF) that | + | '''Description of YLR425W:''' Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate<ref name='S000040642'>Helliwell SB, et al. (1998) TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148(1):99-112 {{SGDpaper|S000040642}} PMID 9475724</ref><ref name='S000148494'>Krause SA, et al. (2012) Functional specialization of the yeast Rho1 GTP exchange factors. J Cell Sci () {{SGDpaper|S000148494}} PMID 22344253</ref><ref name='S000069495'>Schmelzle T, et al. (2002) Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol 22(5):1329-39 {{SGDpaper|S000069495}} PMID 11839800</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 |
{{SGDpaper|S000074306}} PMID 14574415</ref> | {{SGDpaper|S000074306}} PMID 14574415</ref> | ||
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Latest revision as of 14:05, 17 March 2012
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| Systematic name | YLR425W |
| Gene name | TUS1 |
| Aliases | SOP10 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:982894..986817 |
| Primary SGDID | S000004417 |
Description of YLR425W: Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate[1][2][3][4]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
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References
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- ↑ Helliwell SB, et al. (1998) TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148(1):99-112 SGD PMID 9475724
- ↑ Krause SA, et al. (2012) Functional specialization of the yeast Rho1 GTP exchange factors. J Cell Sci () SGD PMID 22344253
- ↑ Schmelzle T, et al. (2002) Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol 22(5):1329-39 SGD PMID 11839800
- ↑ 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ submitted by Jeff Ubersax on 2004-01-29
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