Difference between revisions of "YLR425W"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:18, 30 January 2007

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Systematic name YLR425W
Gene name TUS1
Aliases SOP10
Feature type ORF, Verified
Coordinates Chr XII:982891..986814


Description of YLR425W: Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate[1][2][3]




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Community Commentary

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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [4]


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References

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  1. 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  2. Schmelzle T, et al. (2002) Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol 22(5):1329-39 SGD PMID 11839800
  3. Helliwell SB, et al. (1998) TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148(1):99-112 SGD PMID 9475724
  4. submitted by Jeff Ubersax on 2004-01-29

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