Difference between revisions of "YLR403W"

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'''Description of YLR403W:''' Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p; can form the [ISP+] prion<ref name='S000081242'>Cipollina C, et al. (2005) SFP1 is involved in cell size modulation in respiro-fermentative growth conditions. Yeast 22(5):385-99 {{SGDpaper|S000081242}} PMID 15806610</ref><ref name='S000070190'>Jorgensen P, et al. (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297(5580):395-400 {{SGDpaper|S000070190}} PMID 12089449</ref><ref name='S000077407'>Jorgensen P, et al. (2004) A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev 18(20):2491-505 {{SGDpaper|S000077407}} PMID 15466158</ref><ref name='S000129791'>Lempiainen H, et al. (2009) Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling. Mol Cell 33(6):704-16 {{SGDpaper|S000129791}} PMID 19328065</ref><ref name='S000077584'>Marion RM, et al. (2004) Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression. Proc Natl Acad Sci U S A 101(40):14315-22 {{SGDpaper|S000077584}} PMID 15353587</ref><ref name='S000043166'>Xu Z and Norris D (1998) The SFP1 gene product of Saccharomyces cerevisiae regulates G2/M transitions during the mitotic cell cycle and DNA-damage response. Genetics 150(4):1419-28
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'''Description of YLR403W:''' Regulates transcription of ribosomal protein and biogenesis genes; controls expression of ribosomal protein and ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p; single zinc finger with dispersed spacing and analysis of ChIP data suggests it is unlikely to bind DNA directly; can form the [ISP+] prion<ref name='S000058122'>Bohm S, et al. (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9 {{SGDpaper|S000058122}} PMID 9171100</ref><ref name='S000081242'>Cipollina C, et al. (2005) SFP1 is involved in cell size modulation in respiro-fermentative growth conditions. Yeast 22(5):385-99 {{SGDpaper|S000081242}} PMID 15806610</ref><ref name='S000131167'>Gordan R, et al. (2009) Distinguishing direct versus indirect transcription factor-DNA interactions. Genome Res 19(11):2090-100 {{SGDpaper|S000131167}} PMID 19652015</ref><ref name='S000070190'>Jorgensen P, et al. (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297(5580):395-400 {{SGDpaper|S000070190}} PMID 12089449</ref><ref name='S000077407'>Jorgensen P, et al. (2004) A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev 18(20):2491-505 {{SGDpaper|S000077407}} PMID 15466158</ref><ref name='S000129791'>Lempiainen H, et al. (2009) Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling. Mol Cell 33(6):704-16 {{SGDpaper|S000129791}} PMID 19328065</ref><ref name='S000077584'>Marion RM, et al. (2004) Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression. Proc Natl Acad Sci U S A 101(40):14315-22 {{SGDpaper|S000077584}} PMID 15353587</ref><ref name='S000043166'>Xu Z and Norris D (1998) The SFP1 gene product of Saccharomyces cerevisiae regulates G2/M transitions during the mitotic cell cycle and DNA-damage response. Genetics 150(4):1419-28
 
  {{SGDpaper|S000043166}} PMID 9832520</ref>
 
  {{SGDpaper|S000043166}} PMID 9832520</ref>
 
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Revision as of 14:05, 29 March 2012

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Systematic name YLR403W
Gene name SFP1
Aliases [ISP(+)], [ISP+]
Feature type ORF, Verified
Coordinates Chr XII:925568..927619
Primary SGDID S000004395


Description of YLR403W: Regulates transcription of ribosomal protein and biogenesis genes; controls expression of ribosomal protein and ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p; single zinc finger with dispersed spacing and analysis of ChIP data suggests it is unlikely to bind DNA directly; can form the [ISP+] prion[1][2][3][4][5][6][7][8]




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References

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  1. Bohm S, et al. (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9 SGD PMID 9171100
  2. Cipollina C, et al. (2005) SFP1 is involved in cell size modulation in respiro-fermentative growth conditions. Yeast 22(5):385-99 SGD PMID 15806610
  3. Gordan R, et al. (2009) Distinguishing direct versus indirect transcription factor-DNA interactions. Genome Res 19(11):2090-100 SGD PMID 19652015
  4. Jorgensen P, et al. (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297(5580):395-400 SGD PMID 12089449
  5. Jorgensen P, et al. (2004) A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev 18(20):2491-505 SGD PMID 15466158
  6. Lempiainen H, et al. (2009) Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling. Mol Cell 33(6):704-16 SGD PMID 19328065
  7. Marion RM, et al. (2004) Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression. Proc Natl Acad Sci U S A 101(40):14315-22 SGD PMID 15353587
  8. Xu Z and Norris D (1998) The SFP1 gene product of Saccharomyces cerevisiae regulates G2/M transitions during the mitotic cell cycle and DNA-damage response. Genetics 150(4):1419-28 SGD PMID 9832520

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