YLR384C
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| Systematic name | YLR384C |
| Gene name | IKI3 |
| Aliases | ELP1, KTI7, TOT1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:892900..888851 |
| Primary SGDID | S000004376 |
Description of YLR384C: Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)[1][2][3][4]
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References
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- ↑ Kishida M, et al. (1996) Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 60(5):798-801 SGD PMID 8704309
- ↑ Rahl PB, et al. (2005) Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell 17(6):841-53 SGD PMID 15780940
- ↑ Frohloff F, et al. (2003) Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex. J Biol Chem 278(2):956-61 SGD PMID 12424236
- ↑ Esberg A, et al. (2006) Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell 24(1):139-48 SGD PMID 17018299
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