Difference between revisions of "YLR384C"

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'''Description of YLR384C:''' Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)<ref name='S000119100'>Esberg A, et al. (2006) Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell 24(1):139-48 {{SGDpaper|S000119100}} PMID 17018299</ref><ref name='S000081229'>Rahl PB, et al. (2005) Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell 17(6):841-53 {{SGDpaper|S000081229}} PMID 15780940</ref><ref name='S000072244'>Frohloff F, et al. (2003) Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex. J Biol Chem 278(2):956-61 {{SGDpaper|S000072244}} PMID 12424236</ref><ref name='S000039845'>Kishida M, et al. (1996) Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 60(5):798-801
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'''Description of YLR384C:''' Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)<ref name='S000039845'>Kishida M, et al. (1996) Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 60(5):798-801 {{SGDpaper|S000039845}} PMID 8704309</ref><ref name='S000081229'>Rahl PB, et al. (2005) Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell 17(6):841-53 {{SGDpaper|S000081229}} PMID 15780940</ref><ref name='S000072244'>Frohloff F, et al. (2003) Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex. J Biol Chem 278(2):956-61 {{SGDpaper|S000072244}} PMID 12424236</ref><ref name='S000119100'>Esberg A, et al. (2006) Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell 24(1):139-48
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  {{SGDpaper|S000119100}} PMID 17018299</ref>
 
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Revision as of 14:05, 31 March 2009

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Systematic name YLR384C
Gene name IKI3
Aliases ELP1, KTI7, TOT1
Feature type ORF, Verified
Coordinates Chr XII:892900..888851
Primary SGDID S000004376


Description of YLR384C: Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)[1][2][3][4]




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References

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  1. Kishida M, et al. (1996) Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 60(5):798-801 SGD PMID 8704309
  2. Rahl PB, et al. (2005) Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell 17(6):841-53 SGD PMID 15780940
  3. Frohloff F, et al. (2003) Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex. J Biol Chem 278(2):956-61 SGD PMID 12424236
  4. Esberg A, et al. (2006) Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell 24(1):139-48 SGD PMID 17018299

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