Difference between revisions of "YLR376C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004368 YLR376C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PSY3 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PSY3 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' '' | ||
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XII: | + | |nowrap| Chr XII:873554..872826 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004368 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004368 | ||
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| − | '''Description of YLR376C:''' | + | '''Description of YLR376C:''' Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C<ref name='S000130520'>Ball LG, et al. (2009) The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol 73(1):89-102 {{SGDpaper|S000130520}} PMID 19496932</ref><ref name='S000147390'>Bernstein KA, et al. (2011) The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase. Mol Biol Cell 22(9):1599-607 {{SGDpaper|S000147390}} PMID 21372173</ref><ref name='S000074096'>Huang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34 {{SGDpaper|S000074096}} PMID 12972632</ref><ref name='S000123652'>Mankouri HW, et al. (2007) Shu proteins promote the formation of homologous recombination intermediates that are processed by sgs1-rmi1-top3. Mol Biol Cell 18(10):4062-73 {{SGDpaper|S000123652}} PMID 17671161</ref><ref name='S000149016'>Tao Y, et al. (2012) Structural analysis of Shu proteins reveals a DNA-binding role essential for resisting damage. J Biol Chem () {{SGDpaper|S000149016}} PMID 22465956</ref><ref name='S000076460'>Wu HI, et al. (2004) Genome-wide identification of genes conferring resistance to the anticancer agents cisplatin, oxaliplatin, and mitomycin C. Cancer Res 64(11):3940-8 |
| − | {{SGDpaper| | + | {{SGDpaper|S000076460}} PMID 15173006</ref> |
<br> | <br> | ||
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Latest revision as of 14:05, 26 April 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YLR376C |
| Gene name | PSY3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:873554..872826 |
| Primary SGDID | S000004368 |
Description of YLR376C: Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C[1][2][3][4][5][6]
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References
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- ↑ Ball LG, et al. (2009) The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol 73(1):89-102 SGD PMID 19496932
- ↑ Bernstein KA, et al. (2011) The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase. Mol Biol Cell 22(9):1599-607 SGD PMID 21372173
- ↑ Huang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34 SGD PMID 12972632
- ↑ Mankouri HW, et al. (2007) Shu proteins promote the formation of homologous recombination intermediates that are processed by sgs1-rmi1-top3. Mol Biol Cell 18(10):4062-73 SGD PMID 17671161
- ↑ Tao Y, et al. (2012) Structural analysis of Shu proteins reveals a DNA-binding role essential for resisting damage. J Biol Chem () SGD PMID 22465956
- ↑ Wu HI, et al. (2004) Genome-wide identification of genes conferring resistance to the anticancer agents cisplatin, oxaliplatin, and mitomycin C. Cancer Res 64(11):3940-8 SGD PMID 15173006
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