YLR347C

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Systematic name YLR347C
Gene name KAP95
Aliases RSL1
Feature type ORF, Verified
Coordinates Chr XII:826412..823827
Primary SGDID S000004339


Description of YLR347C: Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p[1][2][3][4][5]




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References

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  1. Enenkel C, et al. (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270(28):16499-502 SGD PMID 7622450
  2. Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7 SGD PMID 8849456
  3. Gilchrist D and Rexach M (2003) Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem 278(51):51937-49 SGD PMID 14514698
  4. Mackinnon MA, et al. (2009) The kap60-kap95 karyopherin complex directly regulates phosphatidylcholine synthesis. J Biol Chem 284(11):7376-84 SGD PMID 19141610
  5. Lonhienne TG, et al. (2009) Importin-Beta is a GDP-TO-GTP exchange factor of RAN: Implications for the mechanism of nuclear import. J Biol Chem SGD PMID 19549784

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