Difference between revisions of "YLR347C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004339 YLR347C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''KAP95 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''KAP95 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XII: | + | |nowrap| Chr XII:826413..823828 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004339 | ||
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| − | '''Description of | + | '''Description of YLR347C:''' Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p<ref name='S000049555'>Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7 {{SGDpaper|S000049555}} PMID 8849456</ref><ref name='S000046571'>Enenkel C, et al. (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270(28):16499-502 {{SGDpaper|S000046571}} PMID 7622450</ref><ref name='S000074600'>Gilchrist D and Rexach M (2003) Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem 278(51):51937-49 {{SGDpaper|S000074600}} PMID 14514698</ref><ref name='S000130748'>Lonhienne TG, et al. (2009) Importin-{beta} Is a GDP-to-GTP Exchange Factor of Ran: IMPLICATIONS FOR THE MECHANISM OF NUCLEAR IMPORT. J Biol Chem 284(34):22549-58 {{SGDpaper|S000130748}} PMID 19549784</ref><ref name='S000128919'>Mackinnon MA, et al. (2009) The kap60-kap95 karyopherin complex directly regulates phosphatidylcholine synthesis. J Biol Chem 284(11):7376-84 |
| − | {{SGDpaper| | + | {{SGDpaper|S000128919}} PMID 19141610</ref> |
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==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 07:45, 23 January 2012
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| Systematic name | YLR347C |
| Gene name | KAP95 |
| Aliases | RSL1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:826413..823828 |
| Primary SGDID | S000004339 |
Description of YLR347C: Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p[1][2][3][4][5]
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References
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- ↑ Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7 SGD PMID 8849456
- ↑ Enenkel C, et al. (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270(28):16499-502 SGD PMID 7622450
- ↑ Gilchrist D and Rexach M (2003) Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem 278(51):51937-49 SGD PMID 14514698
- ↑ Lonhienne TG, et al. (2009) Importin-{beta} Is a GDP-to-GTP Exchange Factor of Ran: IMPLICATIONS FOR THE MECHANISM OF NUCLEAR IMPORT. J Biol Chem 284(34):22549-58 SGD PMID 19549784
- ↑ Mackinnon MA, et al. (2009) The kap60-kap95 karyopherin complex directly regulates phosphatidylcholine synthesis. J Biol Chem 284(11):7376-84 SGD PMID 19141610
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