Difference between revisions of "YLR347C"

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'''Description of YLR347C:''' Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex<ref name='S000074600'>Gilchrist D and Rexach M (2003) Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem 278(51):51937-49 {{SGDpaper|S000074600}} PMID 14514698</ref><ref name='S000049555'>Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7
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'''Description of YLR347C:''' Karyopherin beta, forms a complex with Srp1p/Kap60p; mediates nuclear import of cargo proteins via a nuclear localization signal; involved in PC biosynthesis; interacts with nucleoporins to guide transport across the nuclear pore comple<ref name='S000128919'>Mackinnon MA, et al. (2009) The Kap60/Kap95 Karyopherin Complex Directly Regulates Phosphatidylcholine Synthesis. J Biol Chem {{SGDpaper|S000128919}} PMID 19141610</ref><ref name='S000074600'>Gilchrist D and Rexach M (2003) Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem 278(51):51937-49 {{SGDpaper|S000074600}} PMID 14514698</ref><ref name='S000049555'>Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7 {{SGDpaper|S000049555}} PMID 8849456</ref><ref name='S000046571'>Enenkel C, et al. (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270(28):16499-502
  {{SGDpaper|S000049555}} PMID 8849456</ref>
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  {{SGDpaper|S000046571}} PMID 7622450</ref>
 
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Revision as of 07:21, 26 February 2009

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Systematic name YLR347C
Gene name KAP95
Aliases RSL1
Feature type ORF, Verified
Coordinates Chr XII:826412..823827
Primary SGDID S000004339


Description of YLR347C: Karyopherin beta, forms a complex with Srp1p/Kap60p; mediates nuclear import of cargo proteins via a nuclear localization signal; involved in PC biosynthesis; interacts with nucleoporins to guide transport across the nuclear pore comple[1][2][3][4]




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References

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  1. Mackinnon MA, et al. (2009) The Kap60/Kap95 Karyopherin Complex Directly Regulates Phosphatidylcholine Synthesis. J Biol Chem SGD PMID 19141610
  2. Gilchrist D and Rexach M (2003) Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem 278(51):51937-49 SGD PMID 14514698
  3. Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7 SGD PMID 8849456
  4. Enenkel C, et al. (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270(28):16499-502 SGD PMID 7622450

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