YLR332W

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Systematic name YLR332W
Gene name MID2
Aliases KAI1
Feature type ORF, Verified
Coordinates Chr XII:790676..791806
Primary SGDID S000004324


Description of YLR332W: O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p[1][2]




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Community Commentary

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Transmembrane Domain GxxxG

The transmembrane domain of Mid2p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with iviGcvvG. The presence of GxxxG motifs [3] strongly indicates that Mid2p dimerisation.



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References

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  1. Green R, et al. (2003) A synthetic analysis of the Saccharomyces cerevisiae stress sensor Mid2p, and identification of a Mid2p-interacting protein, Zeo1p, that modulates the PKC1-MPK1 cell integrity pathway. Microbiology 149(Pt 9):2487-99 SGD PMID 12949174
  2. Philip B and Levin DE (2001) Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1. Mol Cell Biol 21(1):271-80 SGD PMID 11113201
  3. Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242

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