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Systematic name YLR329W
Gene name REC102
Feature type ORF, Verified
Coordinates Chr XII:786442..787333
Primary SGDID S000004321

Description of YLR329W: Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination[1][2][3]


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Physical interaction with Rec104
Immunoprecipitation and two-hybrid interactions. Both proteins are mutually interdependent for nuclear localization and association with meiotic chromosomes, and both also depend on Spo11p and Ski8p for chromatin association. [4] [5]

Protein Details

Protein Localization

Localized to nucleus and associates with meiotic chromosomes, dependent on Rec104p. Chromatin immunoprecipitation and indirect immunofluorescence reveal substantial localization to chromatin loops (as opposed to axes). Chromatin association is abruptly lost during the pachytene stage. [4] [5]



See Help:References on how to add references

  1. Bhargava J, et al. (1992) The rec102 mutant of yeast is defective in meiotic recombination and chromosome synapsis. Genetics 130(1):59-69 SGD PMID 1732169
  2. Jiao K, et al. (2003) Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p. Mol Cell Biol 23(16):5928-38 SGD PMID 12897161
  3. Malone RE, et al. (1991) Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 128(1):79-88 SGD PMID 2060778
  4. 4.0 4.1 Kee K, et al. (2004) Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8):1815-24 SGD PMID 15044957
  5. 5.0 5.1 submitted by Scott Keeney on 2005-12-09

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