Difference between revisions of "YLR218C"

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{|{{Prettytable}} align = 'right' width = '200px'
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YLR218C YLR218C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004208 YLR218C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||'' ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''COA4 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||'' ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''CMC3''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Uncharacterized[[Category:ORF]][[Category:ORF, Uncharacterized]]
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XII:573920..573468
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|nowrap| Chr XII:573918..573466
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000004208
 
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'''Description of {{PAGENAME}}:''' Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR218C is not essential; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source<ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000072525'>Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4 {{SGDpaper|S000072525}} PMID 12134146</ref><ref name='S000071347'>Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 {{SGDpaper|S000071347}} PMID 12140549</ref><ref name='S000070094'>Wilson WA, et al. (2002) Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level. Mol Cell Proteomics 1(3):232-42
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'''Description of YLR218C:''' Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors<ref name='S000135040'>Bestwick M, et al. (2010) Analysis of Leigh Syndrome Mutations in the Yeast SURF1 Homolog Reveals a New Member of the Cytochrome Oxidase Assembly Factor Family. Mol Cell Biol 30(18):4480-91 {{SGDpaper|S000135040}} PMID 20624914</ref><ref name='S000131381'>Longen S, et al. (2009) Systematic analysis of the twin cx(9)c protein family. J Mol Biol 393(2):356-68 {{SGDpaper|S000131381}} PMID 19703468</ref><ref name='S000072525'>Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
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  {{SGDpaper|S000070094}} PMID 12096123</ref>
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  {{SGDpaper|S000072525}} PMID 12134146</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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<!--
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Latest revision as of 07:45, 23 January 2012

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Systematic name YLR218C
Gene name COA4
Aliases CMC3
Feature type ORF, Verified
Coordinates Chr XII:573918..573466
Primary SGDID S000004208


Description of YLR218C: Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors[1][2][3]




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References

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  1. ↑ Bestwick M, et al. (2010) Analysis of Leigh Syndrome Mutations in the Yeast SURF1 Homolog Reveals a New Member of the Cytochrome Oxidase Assembly Factor Family. Mol Cell Biol 30(18):4480-91 SGD PMID 20624914
  2. ↑ Longen S, et al. (2009) Systematic analysis of the twin cx(9)c protein family. J Mol Biol 393(2):356-68 SGD PMID 19703468
  3. ↑ Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4 SGD PMID 12134146

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