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Systematic name YLR182W
Gene name SWI6
Aliases PSL8, SDS11
Feature type ORF, Verified
Coordinates Chr XII:517940..520351
Primary SGDID S000004172

Description of YLR182W: Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators[1][2][3][4][5][6][7]


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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [8] [9]



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  1. Ho Y, et al. (1999) Regulation of transcription at the Saccharomyces cerevisiae start transition by Stb1, a Swi6-binding protein. Mol Cell Biol 19(8):5267-78 SGD PMID 10409718
  2. Horak CE, et al. (2002) Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes Dev 16(23):3017-33 SGD PMID 12464632
  3. Kim KY, et al. (2010) Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Mol Biol Cell 21(9):1609-19 SGD PMID 20219973
  4. Leem SH, et al. (1998) Meiotic role of SWI6 in Saccharomyces cerevisiae. Nucleic Acids Res 26(13):3154-8 SGD PMID 9628912
  5. SGD (2007) Information without a citation in SGD SGD PMID
  6. Scrimale T, et al. (2009) The Unfolded Protein Response Is Induced by the Cell Wall Integrity Mitogen-activated Protein Kinase Signaling Cascade and Is Required for Cell Wall Integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(1):164-75 SGD PMID 18971375
  7. Sidorova JM, et al. (1995) Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization. Mol Biol Cell 6(12):1641-58 SGD PMID 8590795
  8. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  9. submitted by Jeff Ubersax on 2004-01-29

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