Difference between revisions of "YLR182W"

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'''Description of YLR182W:''' Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate<ref name='S000071810'>Horak CE, et al. (2002) Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes Dev 16(23):3017-33 {{SGDpaper|S000071810}} PMID 12464632</ref><ref name='S000041257'>Leem SH, et al. (1998) Meiotic role of SWI6 in Saccharomyces cerevisiae. Nucleic Acids Res 26(13):3154-8 {{SGDpaper|S000041257}} PMID 9628912</ref><ref name='S000073348'>SGD (2007) Information without a citation in SGD  {{SGDpaper|S000073348}} PMID </ref><ref name='S000053728'>Sidorova JM, et al. (1995) Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization. Mol Biol Cell 6(12):1641-58 {{SGDpaper|S000053728}} PMID 8590795</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
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'''Description of YLR182W:''' Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization<ref name='S000071810'>Horak CE, et al. (2002) Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes Dev 16(23):3017-33 {{SGDpaper|S000071810}} PMID 12464632</ref><ref name='S000133411'>Kim KY, et al. (2010) Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Mol Biol Cell 21(9):1609-19 {{SGDpaper|S000133411}} PMID 20219973</ref><ref name='S000041257'>Leem SH, et al. (1998) Meiotic role of SWI6 in Saccharomyces cerevisiae. Nucleic Acids Res 26(13):3154-8 {{SGDpaper|S000041257}} PMID 9628912</ref><ref name='S000073348'>SGD (2007) Information without a citation in SGD  {{SGDpaper|S000073348}} PMID </ref><ref name='S000053728'>Sidorova JM, et al. (1995) Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization. Mol Biol Cell 6(12):1641-58 {{SGDpaper|S000053728}} PMID 8590795</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
 
  {{SGDpaper|S000074306}} PMID 14574415</ref>
 
  {{SGDpaper|S000074306}} PMID 14574415</ref>
 
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Revision as of 14:05, 29 November 2010

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Systematic name YLR182W
Gene name SWI6
Aliases PSL8, SDS11
Feature type ORF, Verified
Coordinates Chr XII:517942..520353
Primary SGDID S000004172


Description of YLR182W: Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization[1][2][3][4][5][6]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]





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References

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  1. Horak CE, et al. (2002) Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes Dev 16(23):3017-33 SGD PMID 12464632
  2. Kim KY, et al. (2010) Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Mol Biol Cell 21(9):1609-19 SGD PMID 20219973
  3. Leem SH, et al. (1998) Meiotic role of SWI6 in Saccharomyces cerevisiae. Nucleic Acids Res 26(13):3154-8 SGD PMID 9628912
  4. SGD (2007) Information without a citation in SGD SGD PMID
  5. Sidorova JM, et al. (1995) Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization. Mol Biol Cell 6(12):1641-58 SGD PMID 8590795
  6. 6.0 6.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  7. submitted by Jeff Ubersax on 2004-01-29

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