Difference between revisions of "YLR079W"

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'''Description of YLR079W:''' Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1<ref name='S000080407'>Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 {{SGDpaper|S000080407}} PMID 15649124</ref><ref name='S000074398'>Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21 {{SGDpaper|S000074398}} PMID 11734846</ref><ref name='S000062149'>Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60 {{SGDpaper|S000062149}} PMID 9334303</ref><ref name='S000058226'>Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 {{SGDpaper|S000058226}} PMID 9346238</ref><ref name='S000057743'>Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 {{SGDpaper|S000057743}} PMID 8421781</ref><ref name='S000050766'>Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 {{SGDpaper|S000050766}} PMID 7958845</ref><ref name='S000045057'>Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 {{SGDpaper|S000045057}} PMID 8164683</ref><ref name='S000043548'>Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 {{SGDpaper|S000043548}} PMID 7954792</ref><ref name='S000041398'>Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30
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'''Description of YLR079W:''' Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1<ref name='S000041398'>Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 {{SGDpaper|S000041398}} PMID 9346239</ref><ref name='S000043548'>Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 {{SGDpaper|S000043548}} PMID 7954792</ref><ref name='S000045057'>Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 {{SGDpaper|S000045057}} PMID 8164683</ref><ref name='S000050766'>Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 {{SGDpaper|S000050766}} PMID 7958845</ref><ref name='S000057743'>Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 {{SGDpaper|S000057743}} PMID 8421781</ref><ref name='S000058226'>Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 {{SGDpaper|S000058226}} PMID 9346238</ref><ref name='S000062149'>Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60 {{SGDpaper|S000062149}} PMID 9334303</ref><ref name='S000080407'>Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 {{SGDpaper|S000080407}} PMID 15649124</ref><ref name='S000074398'>Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21
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Revision as of 14:05, 31 March 2009

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Systematic name YLR079W
Gene name SIC1
Aliases SDB25
Feature type ORF, Verified
Coordinates Chr XII:286821..287675
Primary SGDID S000004069


Description of YLR079W: Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1[1][2][3][4][5][6][7][8][9]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [10] [11]




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References

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  1. ↑ Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 SGD PMID 9346239
  2. ↑ Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 SGD PMID 7954792
  3. ↑ Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 SGD PMID 8164683
  4. ↑ Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 SGD PMID 7958845
  5. ↑ Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 SGD PMID 8421781
  6. ↑ Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 SGD PMID 9346238
  7. ↑ Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60 SGD PMID 9334303
  8. ↑ Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 SGD PMID 15649124
  9. ↑ Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21 SGD PMID 11734846
  10. ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  11. ↑ submitted by Jeff Ubersax on 2004-01-29

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