Difference between revisions of "YLL043W"
SGDwikiBot (talk | contribs) (Automated import of articles) |
SGDwikiBot (talk | contribs) (Automated import of articles) |
||
| (8 intermediate revisions by 2 users not shown) | |||
| Line 4: | Line 4: | ||
{|{{Prettytable}} align = 'right' width = '200px' | {|{{Prettytable}} align = 'right' width = '200px' | ||
|- | |- | ||
| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003966 YLL043W] |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FPS1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FPS1 '' | ||
| Line 13: | Line 13: | ||
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XII: | + | |nowrap| Chr XII:49938..51947 |
| + | |- | ||
| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003966 | ||
|} | |} | ||
<br> | <br> | ||
| − | '''Description of | + | '''Description of YLL043W:''' Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress<ref name='S000046364'>Luyten K, et al. (1995) Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J 14(7):1360-71 {{SGDpaper|S000046364}} PMID 7729414</ref><ref name='S000123333'>Mollapour M and Piper PW (2007) Hog1 mitogen-activated protein kinase phosphorylation targets the yeast fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic Acid. Mol Cell Biol 27(18):6446-56 {{SGDpaper|S000123333}} PMID 17620418</ref><ref name='S000044207'>Tamas MJ, et al. (1999) Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol 31(4):1087-104 {{SGDpaper|S000044207}} PMID 10096077</ref><ref name='S000060866'>Wysocki R, et al. (2001) The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Mol Microbiol 40(6):1391-401 |
| − | {{SGDpaper| | + | {{SGDpaper|S000060866}} PMID 11442837</ref> |
<br> | <br> | ||
<br> | <br> | ||
| Line 36: | Line 38: | ||
{{ShortCenteredHR}} | {{ShortCenteredHR}} | ||
| − | + | The main role of Fps1 is export of glycerol for osmoregulation. Fps1 transport function is gated to ensure glycerol accummulation and glycerol release depending on osmotic conditions. The mechanism of gating is not fully understood but requires certain conserved domains of Fps1 and, directly or indirectly, the Hog1 MAPK. | |
<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
| Line 45: | Line 47: | ||
--> | --> | ||
| + | |||
| + | |||
| + | <protect> | ||
| + | |||
| + | ==References== | ||
| + | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
| + | {{RefHelp}} | ||
| + | </protect> | ||
<protect> | <protect> | ||
==References== | ==References== | ||
Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YLL043W |
| Gene name | FPS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:49938..51947 |
| Primary SGDID | S000003966 |
Description of YLL043W: Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress[1][2][3][4]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Protein Details
Protein Function/Process
Disruption of the FPS1 gene for the aquaglyceroporin Fps1p reduced uptake of 73As(III) into cells, conferring resistance to arsenite. The arsenate-resistant phenotype could be functionally complemented by expression of AQP9, a mammalian homologue [5] [6]
The main role of Fps1 is export of glycerol for osmoregulation. Fps1 transport function is gated to ensure glycerol accummulation and glycerol release depending on osmotic conditions. The mechanism of gating is not fully understood but requires certain conserved domains of Fps1 and, directly or indirectly, the Hog1 MAPK.
<protect>
References
See Help:References on how to add references
- ↑ Luyten K, et al. (1995) Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J 14(7):1360-71 SGD PMID 7729414
- ↑ Mollapour M and Piper PW (2007) Hog1 mitogen-activated protein kinase phosphorylation targets the yeast fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic Acid. Mol Cell Biol 27(18):6446-56 SGD PMID 17620418
- ↑ Tamas MJ, et al. (1999) Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol 31(4):1087-104 SGD PMID 10096077
- ↑ Wysocki R, et al. (2001) The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Mol Microbiol 40(6):1391-401 SGD PMID 11442837
- ↑ Liu Z, et al. (2002) Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci U S A 99(9):6053-8 SGD PMID 11972053
- ↑ submitted by Barry Rosen on 2003-07-31
See Help:Categories on how to add the wiki page for this gene to a Category </protect> <protect>
References
See Help:References on how to add references
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
