Difference between revisions of "YKR019C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YKR019C YKR019C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001727 YKR019C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''IRS4 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''IRS4 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XI:477706..475859
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|nowrap| Chr XI:478063..476216
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001727
 
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'''Description of {{PAGENAME}}:''' Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p; mutation confers an increase in rDNA silencing<ref name='S000054483'>Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97
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'''Description of YKR019C:''' EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS<ref name='S000125665'>Bugnicourt A, et al. (2008) Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Traffic 9(5):755-69 {{SGDpaper|S000125665}} PMID 18298591</ref><ref name='S000040062'>Paoluzi S, et al. (1998) Recognition specificity of individual EH domains of mammals and yeast. EMBO J 17(22):6541-50 {{SGDpaper|S000040062}} PMID 9822599</ref><ref name='S000054483'>Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97
 
  {{SGDpaper|S000054483}} PMID 10082585</ref>
 
  {{SGDpaper|S000054483}} PMID 10082585</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YKR019C
Gene name IRS4
Aliases
Feature type ORF, Verified
Coordinates Chr XI:478063..476216
Primary SGDID S000001727


Description of YKR019C: EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS[1][2][3]




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References

See Help:References on how to add references

  1. Bugnicourt A, et al. (2008) Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Traffic 9(5):755-69 SGD PMID 18298591
  2. Paoluzi S, et al. (1998) Recognition specificity of individual EH domains of mammals and yeast. EMBO J 17(22):6541-50 SGD PMID 9822599
  3. Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97 SGD PMID 10082585

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