YKR016W

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Systematic name YKR016W
Gene name FCJ1
Aliases AIM28, FMP13
Feature type ORF, Verified
Coordinates Chr XI:469717..471339
Primary SGDID S000001724


Description of YKR016W: Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MitOS or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane[1][2][3][4]




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References

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  1. Frederick RL, et al. (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37 SGD PMID 18245340
  2. Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol () SGD PMID 21987634
  3. Rabl R, et al. (2009) Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol 185(6):1047-63 SGD PMID 19528297
  4. von der Malsburg K, et al. (2011) Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Dev Cell () SGD PMID 21944719

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