Difference between revisions of "YKR016W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001724 YKR016W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001724 YKR016W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''AIM28 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''FCJ1 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''FMP13''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''AIM28, FMP13''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Uncharacterized[[Category:ORF]][[Category:ORF, Uncharacterized]]
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XI:469360..470982
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|nowrap| Chr XI:469717..471339
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001724
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001724
 
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'''Description of YKR016W:''' Mitochondrial protein of unknown function; null mutant is synthetically sick with mitochondrial GTPase Gem1p; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media<ref name='S000125499'>Frederick RL, et al. (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37 {{SGDpaper|S000125499}} PMID 18245340</ref><ref name='S000124966'>Hess D, et al. (2008)   {{SGDpaper|S000124966}} PMID </ref><ref name='S000117178'>Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
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'''Description of YKR016W:''' Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane<ref name='S000125499'>Frederick RL, et al. (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37 {{SGDpaper|S000125499}} PMID 18245340</ref><ref name='S000147113'>Harner M, et al. (2011) The mitochondrial contact site complex, a determinant of mitochondrial architecture.LID - 10.1038/emboj.2011.379 [doi] EMBO J () {{SGDpaper|S000147113}} PMID 22009199</ref><ref name='S000147046'>Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol () {{SGDpaper|S000147046}} PMID 21987634</ref><ref name='S000130666'>Rabl R, et al. (2009) Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol 185(6):1047-63 {{SGDpaper|S000130666}} PMID 19528297</ref><ref name='S000146902'>von der Malsburg K, et al. (2011) Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Dev Cell ()
  {{SGDpaper|S000117178}} PMID 16823961</ref>
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  {{SGDpaper|S000146902}} PMID 21944719</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YKR016W
Gene name FCJ1
Aliases AIM28, FMP13
Feature type ORF, Verified
Coordinates Chr XI:469717..471339
Primary SGDID S000001724


Description of YKR016W: Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane[1][2][3][4][5]




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References

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  1. Frederick RL, et al. (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37 SGD PMID 18245340
  2. Harner M, et al. (2011) The mitochondrial contact site complex, a determinant of mitochondrial architecture.LID - 10.1038/emboj.2011.379 [doi] EMBO J () SGD PMID 22009199
  3. Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol () SGD PMID 21987634
  4. Rabl R, et al. (2009) Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol 185(6):1047-63 SGD PMID 19528297
  5. von der Malsburg K, et al. (2011) Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Dev Cell () SGD PMID 21944719

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