Difference between revisions of "YKR016W"

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'''Description of YKR016W:''' Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance<ref name='S000125499'>Frederick RL, et al. (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37 {{SGDpaper|S000125499}} PMID 18245340</ref><ref name='S000129658'>Hess DC, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407 {{SGDpaper|S000129658}} PMID 19300474</ref><ref name='S000130666'>Rabl R, et al. (2009) Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol 185(6):1047-63
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'''Description of YKR016W:''' Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a subunit of the mitochondrial inner membrane organizing system (MINOS) complex<ref name='S000125499'>Frederick RL, et al. (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37 {{SGDpaper|S000125499}} PMID 18245340</ref><ref name='S000130666'>Rabl R, et al. (2009) Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol 185(6):1047-63 {{SGDpaper|S000130666}} PMID 19528297</ref><ref name='S000146902'>von der Malsburg K, et al. (2011) Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Dev Cell ()
  {{SGDpaper|S000130666}} PMID 19528297</ref>
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  {{SGDpaper|S000146902}} PMID 21944719</ref>
 
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Revision as of 14:05, 29 September 2011

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Systematic name YKR016W
Gene name FCJ1
Aliases AIM28, FMP13
Feature type ORF, Verified
Coordinates Chr XI:469717..471339
Primary SGDID S000001724


Description of YKR016W: Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a subunit of the mitochondrial inner membrane organizing system (MINOS) complex[1][2][3]




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References

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  1. Frederick RL, et al. (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37 SGD PMID 18245340
  2. Rabl R, et al. (2009) Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol 185(6):1047-63 SGD PMID 19528297
  3. von der Malsburg K, et al. (2011) Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Dev Cell () SGD PMID 21944719

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