YKL166C
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| Systematic name | YKL166C |
| Gene name | TPK3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:135710..134514 |
| Primary SGDID | S000001649 |
Description of YKL166C: Subunit of cAMP-dependent protein kinase, which contains Tpk1p, Tpk2p, Tpk3p, and regulatory subunit Bcy1p; promotes growth in response to nutrients; mediates induction of apoptosis due to actin-mediated hyperactivation of Ras signaling[1][2][3][4][5]
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Community Commentary
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Interactions
Genetic
Strain Background: S288C, W303, industrial
Genetic interaction with ATF1
Mutation type(s): deletion/partial inactivating
ATF1 is transcriptionally induced by glucose and sucrose. This regulation depends on Ras/cAMP/PKA signaling. Long-term expression of ATF1 requires both a fermentable carbon source and a nitrogen source. This regulation depends on FGM signaling. [6] [7]
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References
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- ↑ Gourlay CW and Ayscough KR (2006) Actin-induced hyperactivation of the Ras signaling pathway leads to apoptosis in Saccharomyces cerevisiae. Mol Cell Biol 26(17):6487-501 SGD PMID 16914733
- ↑ Pan X and Heitman J (1999) Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol Cell Biol 19(7):4874-87 SGD PMID 10373537
- ↑ Toda T, et al. (1987) Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 7(4):1371-7 SGD PMID 3037314
- ↑ Ordiz I, et al. (1996) Glucose-induced inactivation of isocitrate lyase in Saccharomyces cerevisiae is mediated by the cAMP-dependent protein kinase catalytic subunits Tpk1 and Tpk2. FEBS Lett 385(1-2):43-6 SGD PMID 8641464
- ↑ Toda T, et al. (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50(2):277-87 SGD PMID 3036373
- ↑ Verstrepen KJ, et al. (2003) The Saccharomyces cerevisiae alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathways. FEMS Yeast Res 4(3):285-96 SGD PMID 14654433
- ↑ submitted by Kevin J Verstrepen on 2004-03-11
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