Difference between revisions of "YKL126W"
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| − | '''Description of YKL126W:''' Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK<ref name='S000053842'>Casamayor A, et al. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97 {{SGDpaper|S000053842}} PMID 10074427</ref><ref name='S000071423'>Roelants FM, et al. (2002) Pkh1 and | + | '''Description of YKL126W:''' Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK<ref name='S000053842'>Casamayor A, et al. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97 {{SGDpaper|S000053842}} PMID 10074427</ref><ref name='S000071423'>Roelants FM, et al. (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28 {{SGDpaper|S000071423}} PMID 12221112</ref><ref name='S000132460'>Roelants FM, et al. (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A 107(1):34-9 {{SGDpaper|S000132460}} PMID 19966303</ref><ref name='S000069495'>Schmelzle T, et al. (2002) Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol 22(5):1329-39 {{SGDpaper|S000069495}} PMID 11839800</ref><ref name='S000046994'>Sun Y, et al. (2000) Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol Cell Biol 20(12):4411-9 {{SGDpaper|S000046994}} PMID 10825204</ref><ref name='S000069470'>deHart AK, et al. (2002) The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J Cell Biol 156(2):241-8 |
{{SGDpaper|S000069470}} PMID 11807089</ref> | {{SGDpaper|S000069470}} PMID 11807089</ref> | ||
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Revision as of 14:05, 1 April 2011
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| Systematic name | YKL126W |
| Gene name | YPK1 |
| Aliases | SLI2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:205707..207749 |
| Primary SGDID | S000001609 |
Description of YKL126W: Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK[1][2][3][4][5][6]
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References
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- ↑ Casamayor A, et al. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97 SGD PMID 10074427
- ↑ Roelants FM, et al. (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28 SGD PMID 12221112
- ↑ Roelants FM, et al. (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A 107(1):34-9 SGD PMID 19966303
- ↑ Schmelzle T, et al. (2002) Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol 22(5):1329-39 SGD PMID 11839800
- ↑ Sun Y, et al. (2000) Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol Cell Biol 20(12):4411-9 SGD PMID 10825204
- ↑ deHart AK, et al. (2002) The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J Cell Biol 156(2):241-8 SGD PMID 11807089
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