Difference between revisions of "YKL088W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001571 YKL088W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001571 YKL088W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''CAB3 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''CAB3 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XI:274927..276642
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|nowrap| Chr XI:275283..276998
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001571
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001571
 
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'''Description of YKL088W:''' Probable phosphopantothenoylcysteine decarboxylase (PPCDC), which catalyzes the third step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC; interacts with Sis2p and Vhs3p<ref name='S000072463'>Tatusov RL, et al. (2000) The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res 28(1):33-6 {{SGDpaper|S000072463}} PMID 10592175</ref><ref name='S000075214'>Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65 {{SGDpaper|S000075214}} PMID 14690591</ref><ref name='S000129524'>Olzhausen J, et al. (2009) Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet
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'''Description of YKL088W:''' Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC<ref name='S000075214'>Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65 {{SGDpaper|S000075214}} PMID 14690591</ref><ref name='S000129524'>Olzhausen J, et al. (2009) Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet 55(2):163-73 {{SGDpaper|S000129524}} PMID 19266201</ref><ref name='S000132230'>Ruiz A, et al. (2009) Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol 5(12):920-8 {{SGDpaper|S000132230}} PMID 19915539</ref><ref name='S000072463'>Tatusov RL, et al. (2000) The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res 28(1):33-6
  {{SGDpaper|S000129524}} PMID 19266201</ref>
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  {{SGDpaper|S000072463}} PMID 10592175</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YKL088W
Gene name CAB3
Aliases
Feature type ORF, Verified
Coordinates Chr XI:275283..276998
Primary SGDID S000001571


Description of YKL088W: Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC[1][2][3][4]




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References

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  1. Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65 SGD PMID 14690591
  2. Olzhausen J, et al. (2009) Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet 55(2):163-73 SGD PMID 19266201
  3. Ruiz A, et al. (2009) Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol 5(12):920-8 SGD PMID 19915539
  4. Tatusov RL, et al. (2000) The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res 28(1):33-6 SGD PMID 10592175

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