Difference between revisions of "YJR119C"

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'''Description of YJR119C:''' JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation<ref name='S000121023'>Seward DJ, et al. (2007) Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol 14(3):240-2 {{SGDpaper|S000121023}} PMID 17310255</ref><ref name='S000121024'>Liang G, et al. (2007) Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. Nat Struct Mol Biol 14(3):243-5 {{SGDpaper|S000121024}} PMID 17310254</ref><ref name='S000121921'>Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 {{SGDpaper|S000121921}} PMID 17369256</ref><ref name='S000129902'>Mersman DP, et al. (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev
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'''Description of YJR119C:''' JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation<ref name='S000121023'>Seward DJ, et al. (2007) Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol 14(3):240-2 {{SGDpaper|S000121023}} PMID 17310255</ref><ref name='S000121024'>Liang G, et al. (2007) Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. Nat Struct Mol Biol 14(3):243-5 {{SGDpaper|S000121024}} PMID 17310254</ref><ref name='S000121921'>Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 {{SGDpaper|S000121921}} PMID 17369256</ref><ref name='S000129902'>Mersman DP, et al. (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62
 
  {{SGDpaper|S000129902}} PMID 19346402</ref>
 
  {{SGDpaper|S000129902}} PMID 19346402</ref>
 
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Revision as of 14:05, 25 April 2009

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Systematic name YJR119C
Gene name JHD2
Aliases KDM5
Feature type ORF, Verified
Coordinates Chr X:646480..644294
Primary SGDID S000003880


Description of YJR119C: JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation[1][2][3][4]




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References

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  1. Seward DJ, et al. (2007) Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol 14(3):240-2 SGD PMID 17310255
  2. Liang G, et al. (2007) Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. Nat Struct Mol Biol 14(3):243-5 SGD PMID 17310254
  3. Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 SGD PMID 17369256
  4. Mersman DP, et al. (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62 SGD PMID 19346402

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