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Systematic name YJR090C
Gene name GRR1
Aliases CAT80, COT2, SDC1, SSU2
Feature type ORF, Verified
Coordinates Chr X:594327..590872
Primary SGDID S000003850

Description of YJR090C: F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification[1][2][3][4][5][6][7][8]


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  1. Avram D and Bakalinsky AT (1996) Multicopy FZF1 (SUL1) suppresses the sulfite sensitivity but not the glucose derepression or aberrant cell morphology of a grr1 mutant of Saccharomyces cerevisiae. Genetics 144(2):511-21 SGD PMID 8889516
  2. Barral Y, et al. (1995) G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev 9(4):399-409 SGD PMID 7883165
  3. Conklin DS, et al. (1993) The COT2 gene is required for glucose-dependent divalent cation transport in Saccharomyces cerevisiae. Mol Cell Biol 13(4):2041-9 SGD PMID 8455597
  4. Erickson JR and Johnston M (1994) Suppressors reveal two classes of glucose repression genes in the yeast Saccharomyces cerevisiae. Genetics 136(4):1271-8 SGD PMID 8013904
  5. Flick JS and Johnston M (1991) GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats. Mol Cell Biol 11(10):5101-12 SGD PMID 1922034
  6. Kim YJ, et al. (1994) Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation. J Cell Biol 127(5):1381-94 SGD PMID 7962097
  7. Li FN and Johnston M (1997) Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle. EMBO J 16(18):5629-38 SGD PMID 9312022
  8. Vallier LG, et al. (1994) Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Genetics 136(4):1279-85 SGD PMID 8013905

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