Difference between revisions of "YJL092W"

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{|{{Prettytable}} align = 'right' width = '200px'
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YJL092W YJL092W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003628 YJL092W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HPR5 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SRS2 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''RADH, RADH1, SRS2''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''HPR5, RADH, RADH1''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr X:257418..260942
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|nowrap| Chr X:257423..260947
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003628
 
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'''Description of {{PAGENAME}}:''' DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc28p substrate<ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000051638'>Rong L and Klein HL (1993) Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae. J Biol Chem 268(2):1252-9 {{SGDpaper|S000051638}} PMID 8419328</ref><ref name='S000044473'>Aboussekhra A, et al. (1989) RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene. Nucleic Acids Res 17(18):7211-9 {{SGDpaper|S000044473}} PMID 2552405</ref><ref name='S000044035'>Palladino F and Klein HL (1992) Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants. Genetics 132(1):23-37
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'''Description of YJL092W:''' DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability<ref name='S000044473'>Aboussekhra A, et al. (1989) RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene. Nucleic Acids Res 17(18):7211-9 {{SGDpaper|S000044473}} PMID 2552405</ref><ref name='S000126247'>Dhar A and Lahue RS (2008) Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae. Nucleic Acids Res 36(10):3366-73 {{SGDpaper|S000126247}} PMID 18440969</ref><ref name='S000044035'>Palladino F and Klein HL (1992) Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants. Genetics 132(1):23-37 {{SGDpaper|S000044035}} PMID 1327956</ref><ref name='S000086095'>Papouli E, et al. (2005) Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol Cell 19(1):123-33 {{SGDpaper|S000086095}} PMID 15989970</ref><ref name='S000081912'>Pfander B, et al. (2005) SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature 436(7049):428-33 {{SGDpaper|S000081912}} PMID 15931174</ref><ref name='S000051638'>Rong L and Klein HL (1993) Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae. J Biol Chem 268(2):1252-9 {{SGDpaper|S000051638}} PMID 8419328</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000148677'>Yeung M and Durocher D (2011) Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin. DNA Repair (Amst) 10(12):1213-22
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  {{SGDpaper|S000044035}} PMID 1327956</ref>
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  {{SGDpaper|S000148677}} PMID 21982442</ref>
 
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=== Protein Details ===
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==== Protein Modification ====
 
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[[Category:Topic:Protein Details:Protein Modification]]
 
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'''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]]
 
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Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-27</ref>
 
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==Community Commentary==
 
==Community Commentary==
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 14:05, 26 March 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YJL092W
Gene name SRS2
Aliases HPR5, RADH, RADH1
Feature type ORF, Verified
Coordinates Chr X:257423..260947
Primary SGDID S000003628


Description of YJL092W: DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability[1][2][3][4][5][6][7][8]




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Community Commentary

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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [7] [9]




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References

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  1. ↑ Aboussekhra A, et al. (1989) RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene. Nucleic Acids Res 17(18):7211-9 SGD PMID 2552405
  2. ↑ Dhar A and Lahue RS (2008) Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae. Nucleic Acids Res 36(10):3366-73 SGD PMID 18440969
  3. ↑ Palladino F and Klein HL (1992) Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants. Genetics 132(1):23-37 SGD PMID 1327956
  4. ↑ Papouli E, et al. (2005) Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol Cell 19(1):123-33 SGD PMID 15989970
  5. ↑ Pfander B, et al. (2005) SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature 436(7049):428-33 SGD PMID 15931174
  6. ↑ Rong L and Klein HL (1993) Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae. J Biol Chem 268(2):1252-9 SGD PMID 8419328
  7. ↑ 7.0 7.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  8. ↑ Yeung M and Durocher D (2011) Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin. DNA Repair (Amst) 10(12):1213-22 SGD PMID 21982442
  9. ↑ submitted by Jeff Ubersax on 2004-01-27

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